Love the effort by GitHub to support folks like me who have a hard time distinguishing colours. I was unable to use their original Dark Mode, however I found Dark Mode Dimmed to be a bit better.
My one main critique with the new Colorblind Mode is that for pull requests, the “Open” and the “Merged” tag are the same colour now. This makes it harder at-a-glance to determine the state of the PR. It would be awesome if these could be different colours (before the Merged one was a blue color and the Open was green).