Blue/orange vs orange-red / blue-green

The - and + are way more distinct now, but there’s no cultural association with blue/orange the way there is with red/green.

With traffic lights, the solution has been to push red lights towards orange and green lights towards blue. This separates them for colour deficient people but those without red/green deficiency rarely notice.

May I suggest you consider making the default red a bit more orange, the default green a bit more blue, and perhaps you’ll have something, like traffic lights, that doesn’t require choosing a special viewing option to work optimally.